Composition and form of release
The active substance is Tramadol. The drug is available in various forms – capsules and drops for oral use, rectal suppositories, injectable solution.
It is an effective pain reliever. Tramadol relieves pain attacks of different origins and different strengths, including significant ones. It is used in acute and chronic pain syndrome, acute injuries to prevent pain shock, during diagnostic and therapeutic procedures, as well as during the post-operational period, to relieve pain arising from cancer. It has a fast, strong, and long-lasting effect, like most synthetic opiates. However, it is inferior in efficiency to morphine. When switching from morphine to Tramadol, an increase in dosages is required.
You should restrict its use in case of mild pain
It is not used if the patient is in a state of strong alcoholic intoxication. It is contraindicated in case of allergy to the active substance. It should not be used simultaneously with monoamine oxidase inhibitors.
Prescribing the drug should be done with extreme caution to drug addicts, traumatic brain injury, epilepsy, in the case of abdominal pain of unknown origin.
Avoid long-term use, because it may develop resistance to it, and the effect of the drug will weaken. Drug dependence may also occur.
Use during pregnancy and lactation
Use with great caution, under the supervision of a doctor. There is no full confidence in its complete safety for the woman and the fetus.
Dosage and administration
It is administrated by infusion in 1-2 ampoules (50-100 milligrams) per day. The maximum daily dose is 400 mg. The same dosage is recommended for intramuscular and subcutaneous administration.
Capsules are washed down with water, in the same dosage — from 50 to 400 mg a day. You can take it in drops (the same 50 mg), up to 8 times a day.
If necessary, Tramadol is administrated rectally (after emptying the bowel by inserting a candle behind the sphincter). It is permissible to enter up to 4 times a day.
Intravenous administration provides the fastest effect, which occurs within 5-10 minutes, whereas oral administration will give analgesic effect not earlier than within half an hour. The action lasts for three to five hours.
Do not exceed the recommended dosage, because a single administration of a large dose of Tramadol can cause drug dependence.
In case of overdose, there may be increased side effects (hallucinations, retardation, tachycardia), and severe intoxication, which manifests itself in severe vomiting, collapse, coma, convulsions, depression of the respiratory center may occur as well. In case of overdose, the stomach should be washed and enterosorbents diluted.
If the dosage is not exceeded, then taking this drug rarely causes side effects. In rare cases, side effects include nausea, dizziness, excessive sweating.
It is not used for the treatment of withdrawal syndrome.
Do not combine Tramadol with ethanol.
In the case of a single dose, there is no need to interrupt breastfeeding.
During treatment with the drug, caution should be exercised when driving and engaging in other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.
Tramadol is pharmaceutically incompatible with solutions of diclofenac, indomethacin, phenylbutazone, diazepam, flunitrazepam, nitroglycerin.
Tramadol enhances the action of drugs, CNS depressants, and ethanol.
Inducers of microsomal oxidation (including carbamazepine, barbiturates) reduce the severity of the analgesic effect and the duration of the effect of the drug.
Long-term use of opioid analgesics or barbiturates stimulates the development of cross-tolerance.
Anxiolytics increase the severity of the analgesic effect; the duration of anesthesia increases in combination with barbiturates.
Naloxone activates breathing, eliminating analgesia after the use of opioid analgesics.
MAO inhibitors, furazolidone, procarbazine, antipsychotic drugs (neuroleptics) increase the risk of seizures (lowering the seizure threshold).